VKORC1 Asp36Tyr geographic distribution and its impact on warfarin dose requirements in Egyptians
نویسندگان
چکیده
منابع مشابه
Impact of GGCX, STX1B and FPGS Polymorphisms on Warfarin Dose Requirements in European‐Americans and Egyptians
Genotype-based algorithms that include VKORC1 and CYP2C9 genotypes are less predictive of warfarin dose variability in Africans as opposed to Europeans. Polymorphisms in GGCX, FPGS, or STX1B are associated with warfarin dose requirements in African-Americans. We sought to determine if they influenced warfarin dose in European-Americans, and another African population, specifically Egyptians. We...
متن کاملFrequency of two VKORC1 gene variants and its correlation with warfarin maintenance dose
Warfarin is a commonly-prescribed anticoagulant used to treat and prevent thromboembolic events. The requirement for varying doses of warfarin depends on genetic and environmental components. In this study, the frequency of two single-nucleotide polymorphic variants of the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene (1173 C>T (rs9934438) and 3730 G>A (rs7294)) and its correlatio...
متن کاملEffect of CYP2C9 and VKORC1 genetic variations on warfarin dose requirements in Indian patients.
BACKGROUND Warfarin, an oral anticoagulant is used in patients who are at increased risk of developing blood clots. The management of warfarin therapy is challenging because it shows large inter and intra individual variability in patient response due to factors like age, gender, diet, concurrent drug interactions and variations in CYP2C9 and VKORC1 genes. Studies implicate that polymorphisms i...
متن کاملThe effect of CYP2C9 and VKORC1 genetic polymorphisms on warfarin dose requirements in a pediatric population
OBJECTIVE The aim was to investigate the frequency of genetic polymorphisms of cytochrome P4502C9 (CYP2C9) and vitamin K epoxide reductase complex subunit1 (VKORC1) and determine the effect of these polymorphisms on warfarin dose requirements in pediatric patients. METHODS Fifty-eight pediatric patients with cardiac disease, thrombophilia, or other conditions, taking a stable warfarin dose, a...
متن کاملEffect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
BACKGROUND The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin. METHODS We conducted a retrospective study of European-American patients receiving long-term warfarin maintenance therapy. Multiple linear-regression analysis was used...
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ژورنال
عنوان ژورنال: Thrombosis and Haemostasis
سال: 2013
ISSN: 0340-6245,2567-689X
DOI: 10.1160/th12-10-0789